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If you've never given Strangers With Candy a chance, you're really cheating yourself. I never watched it when it originally aired, because I remember the commercials being more than enough for me to take. Several years later after borrowing all the DVDs from a friend, I finally realized how much I had deprived myself of a really good thing.
The premise of the show was about a 46 year old ex-junkie and ex-convict who wanted to start her life over, and starts by going back to high school. One of the funniest things was that no matter how often other students would pick on her and ridicule her, nobody ever acknowledges her age. And Stephen Colbert was one of the head writers and a regular character on the show, so that's always a plus.